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The effect of smoking in pregnancy on maternal serum inhibin A levels

✍ Scribed by E. L. Ferriman; I. K. Sehmi; R. Jones; H. S. Cuckle

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 141 KB
Volume: 19
Category: Article
ISSN: 0197-3851
DOI: 10.1002/(sici)1097-0223(199904)19:4<372::aid-pd537>3.0.co;2-o

No coin nor oath required. For personal study only.

✦ Synopsis

To assess the effect of smoking on maternal serum, second-trimester inhibin A levels, we studied a database of 1277 women undergoing antenatal serum screening. There were 75 smokers, 1008 non-smokers and 194 women in whom smoking status was undetermined. All groups were matched for age, gestation and parity. The median level of inhibin A in smokers was 1•47 multiples of the normal gestation-specific median (MOM) as compared with 1•01 MOM in non-smokers and 0•95 MOM in the undetermined group. The increase was highly statistically significant (p<0•0001, Wilcoxon rank sum test, two-tail). On the basis of these results we conclude that if inhibin A is used as a marker, adjustment for maternal smoking status may be necessary.

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