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The effect of site and type of nerve injury on the expression of brain-derived neurotrophic factor in the dorsal root ganglion and on neuropathic pain behavior

✍ Scribed by K. Obata; H. Yamanaka; K. Kobayashi; Y. Dai; T. Mizushima; H. Katsura; T. Fukuoka; A. Tokunaga; K. Noguchi


Book ID
116787443
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
485 KB
Volume
137
Category
Article
ISSN
0306-4522

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Injury to the sciatic nerve leads to the transganglionic degeneration of sensory axons and to the induction of neurotrophins and p75 nerve growth factor receptor synthesis by the denervated Schwann cells. Sciatic nerve axotomy caused a marked loss of substance P and of met-enkephalin in the lumbar c