The effect of sequential addition of the nitrosourea, chlorozotocin, to the FAM combination in advanced gastric cancer
โ Scribed by Christien Gisselbrecht; Frederick P. Smith; John S. MacDonald; Susan J. Korsmeyer; Michel Boiron; Paul V. Woolley; Philip S. Schein
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 289 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0008-543X
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Forty-eight patients with advanced gastric cancer and measurable areas of malignant disease were treated with etoposide (130 mg/mz/day X 3 days) plus cisplatin (45 mg/mzday on days 2 and 3). Both drugs were given by constant intravenous infusion and repeated every 4 weeks. Common toxic reactions inc
## BACKGROUND. In a randomized Phase I1 study, the authors evaluated the activity and toxicity of the new cisplatin, doxorubicin, and mitomycin C (PAM) comhination, that includes cisplatin (P) instead of 5-fluorouracil as in the 5-fluorouracil, doxorubicin, and mitomycin C (FAM) Combination, in pat