The effect of salt on the Michaelis Menten constant of the HIV-1 protease correlates with the Hofmeister series
โ Scribed by Ewald M. Wondrak; John M. Louis; Stephen Oroszlan
- Book ID
- 115924648
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 435 KB
- Volume
- 280
- Category
- Article
- ISSN
- 0014-5793
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## Abstract The influence of Hofmeister salts was investigated on the cloud point of three poly(2โoxazoline)s, namely poly(2โethylโ2โoxazoline) [PEtOx], poly(2โ__n__โpropylโ2โoxazoline) [P__n__PropOx], and poly(2โisopropylโ2โoxazoline) [P__i__PropOx]. In addition, a comb polymer based on oligoโ2โet
The effects of the peptide inhibitor acetyl pepstatin on the structural stability of the HIV-1 protease have been measured by high sensitivity calorimetric techniques. At 25ยฐC and pH 3.6, acetyl pepstatin binds to HIV-1 protease with an affinity of 1.6 ุ 10 7 M -1 and an enthalpy of 7.3 ุ 0.5 kcal/m