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The Effect of Roentgen Ray Irradiation on Rats Premedicated with Thyroxin and Thiouracil Derivatives†

✍ Scribed by Haley, Thomas J. ;Dowdy, Andrew H. ;Mann, Samuel

Publisher
Elsevier
Year
1952
Weight
271 KB
Volume
41
Category
Article
ISSN
0095-9553

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✦ Synopsis

Hypothyroidism, induced by feeding nontoxic doses of thiouracil and its derivatives, does not significantly increase survival time nor decrease the total mortality of Roentgen ray irradiated rats. Propyl thiouracil significantly increased the rate of and total mortality of Roentgen ray irradiated rats. Hyperthyroidism produced by the subcutaneous injection of thyroxin into rats increased the rate of, and in one experiment, the total mortality of Roentgen ray irradiated rats. It was concluded that the potential sulfhydryl group in the thiouracil compounds is available for protecting the sulfhydryl groups in the animal organism, but a great excess must be present before any protectant effect can be observed. In such cases the drugs would be exerting pharmacological rather than antimetabolic effects.

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