The Effect of Radiotherapy Dose and Volume on Relapse in Merkel Cell Cancer of the Skin
β Scribed by Foote, M.C.; Harvey, J.; Porceddu, S.; Dickie, G.; Hewitt, S.; Colquist, S.; Zarate, D.; Poulsen, M.
- Book ID
- 108148973
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 53 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0360-3016
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## Abstract __Background.__ Merkel cell carcinoma is a relatively rare neuroendocrine carcinoma of the skin. It arises in the head and neck region in approximately 50% of cases. Its aggressive behavior predisposes patients to localβregional recurrence and distant metastases after surgical excision
Since their first description in 1875, Merkel cells have remained an elusive cell type. Their origin as well as their classification as mechanoreceptors have been a matter of controversy and intense discussion. The peptidergic granules in these cells are suggestive of neuroendocrine functions, but t