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The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential

✍ Scribed by Jelmer J. van Zanden; Hester van der Woude; Judith Vaessen; Mustafa Usta; Heleen M. Wortelboer; Nicole H.P. Cnubben; Ivonne M.C.M. Rietjens


Book ID
113488256
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
337 KB
Volume
74
Category
Article
ISSN
0006-2952

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The hepatobiliary disposition of rhodamine 123 (RH-123) and its glucuronidated (RH-Glu) and deacylated (RH-110) metabolites were studied in an isolated perfused rat liver (IPRL) model in the presence and absence of P-glycoprotein (P-gp) and Mrp2 inhibitors. A single dose (180 mg) of RH-123 was added