The effect of Pyrrolo[3,4-c]carbazole derivatives on spinal cord ChAT activity

✍ Scribed by David P. Rotella; Marcie A. Glicksman; J.Eric Prantner; Nicola T. Neff; Robert L. Hudkins

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 198 KB
• Volume: 5
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/0960-894x(95)00188-y

✦ Synopsis

Pyrrolo[3,

carbazole derivatives were prepared as potential neurotrophic agents. The compounds were assayed for their ability to stimulate choline acetyltransferase (CHAT) activity in embryonic rat spinal cord cultures. These simplified K252a derivatives, although less potent and efficacious, have led to the identification of minimal structural requirements for K252a neurotrophic activity.

K252a, 1, is an alkaloid produced by Nocardiopsis sp. K2521 that was originally identified as a protein