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The effect of pretreatment with cimetidine on the bioavailability and disposition of atenolol and metoprolol.

✍ Scribed by JJ Houtzagers; O. Streurman; CG Regardh

Book ID
117943007
Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
633 KB
Volume
14
Category
Article
ISSN
0306-5251

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✍ Carl G. Regardh; Per Lundborg; Bengt A. Persson πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 409 KB πŸ‘ 2 views

## Abstract Concomitant administration of antacid increased the maximum concentration (__Cp__~max~) and the area under the plasma concentration‐time curve (AUC) of 100 mg oral dose of metoprolol by 25 per cent (__p__< 0.05) and 11 per cent (__p__ < 0.1) respectively. For atenolol the opposite effec