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The effect of presenilin on β-amyloid in knock-in mice carrying the human amyloid precursor protein with Swedish and/or London mutation

✍ Scribed by Wiebringhaus, Thomas; Wirak, Dana; Altman, Richard; Cahill, Karyn; Duff, Karen; Ruhland, Manuela; Koenig, Gerhard; Baumann, Karlheinz

Book ID: 122630119
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 199 KB
Volume: 21
Category: Article
ISSN: 0197-4580
DOI: 10.1016/S0197-4580(00)83338-2

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## Abstract The amyloid precursor protein (APP) is cleaved enzymatically by nonamyloidogenic and amyloidogenic pathways. α‐Secretase (α‐secretase), cleaves APP within the β‐amyloid (Aβ) sequence, resulting in the release of a secreted fragment of APP (αAPPs) and precluding Aβ generation. In this st