In this study three model drugs (N-acetyl-D-glucosamine (NAG), anhydrous caffeine, and propranolol hydrochloride) were agglomerated with starch acetate (SA) by mixing the binary powders on a stainless steel (SS) plate. Agglomeration was induced by triboelectrification of the particles during mixing,
The effect of powder blend and tablet structure on drug release mechanisms of hydrophobic starch acetate matrix tablets
β Scribed by B. van Veen; J. Pajander; K. Zuurman; R. Lappalainen; A. Poso; H.W. Frijlink; J. Ketolainen
- Book ID
- 116437422
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- French
- Weight
- 279 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0939-6411
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The aim of this study was to assess the utility of Fourier transform infrared mapping to study the drug release phenomena within a hydrophobic matrix tablet. Starch acetate with a degree of substitution (2.7) was used as a hydrophobic matrix former. Anhydrous caffeine and riboflavin sodium phosphate