✦ LIBER ✦

The Effect of Portal Diversion on the Early Stages of Liver Carcinogenesis in the Rat

✍ Scribed by Lorne E. Rotstein; Leonard Makowka; George Lee; Emmanuel Farber

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 538 KB
Volume: 2
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840020111

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of portal diversion by ameroid constriction was studied in the carcinogenic process in the rat after initiation of foci by diethylnitrosamine and after the establishment of putative preneoplastic nodules. Portal diversion or portal diversion plus partial hepatectomy did not act to promote or select for the development of nodules. Furthermore, portal diversion did not alter the natural history of established nodules. These results suggest that vascular factors are not important at these early stages of the carcinogenic process in the rat liver.

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