The effect of polymorphisms in the promoter region of the MMP-1 gene on the occurrence and invasiveness of hypophyseal adenoma
✍ Scribed by Murat Altaş; Omer Faruk Bayrak; Erdogan Ayan; Fatihhan Bolukbası; Gokalp Sılav; Kerim Kenan Coskun; Mustafa Çulha; Fikrettin Sahin; Serhat Sevli; İlhan Elmacı
- Publisher
- Springer Vienna
- Year
- 2010
- Tongue
- English
- Weight
- 167 KB
- Volume
- 152
- Category
- Article
- ISSN
- 0001-6268
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## Communicated by Stephen Chanock Matrix metalloproteinases (MMPs) play important roles in cancer initiation and development. Several polymorphisms in the promoters of a number of MMP genes, which can affect the respective MMP production in an allele-specific manner, have been well characterized.
By direct sequencing of polymerase chain reaction (PCR) amplified DNA from different individuals, three point mutations have been found in a 220-bp fragment from the promoter region of the human cystatin C gene. The three mutations are all localized within a short segment of 85bp on the same allele.