The effect of phospholipase A2 on chloride transport by pancreatic secretory granules
β Scribed by Kenneth W. Gasser; Jaclyn R. Holda
- Book ID
- 115730823
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 775 KB
- Volume
- 1194
- Category
- Article
- ISSN
- 0005-2736
No coin nor oath required. For personal study only.
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## Abstract It is well known that the expression level of secretory group IIA phospholipase A~2~ (sPLA~2~βIIA) is elevated in inflammatory diseases and lipopolysaccharide (LPS) upβregulates the expression of sPLA~2~βIIA in human umbilical vein endothelial cells (HUVECs). Recently, lower concentrati
Melittin and phospholipase A 2 -activating protein (PLAP) are known as efficient activators of secretory phospholipase A 2 (sPLA 2 ) types I, II, and III when phospholipid liposomes are used as substrate. The present study demonstrates that both peptides can either inhibit or activate sPLA 2 dependi