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The effect of phloretin on single potassium channels in myelinated nerve

✍ Scribed by J. Klusemann; H. Meves

Publisher
Springer
Year
1992
Tongue
English
Weight
409 KB
Volume
21
Category
Article
ISSN
1432-1017

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✦ Synopsis

The effect of phloretin, a dipolar organic compound, on single potassium channel currents of myelinateed nerve fibres of Xenopus laevis has been investigated, using inside-out patches prepared by the method of Jonas et al. (1989). The I channel, a potential dependent K channel with intermediate deactivation kinetics, was reversibly blocked by 20/~M phloretin applied on the inside; the block was strongest at negative membrane potentials and less pronounced at positive potentials. Phloretin shifted the curve relating open probability to membrane potential towards more positive potentials and reduced its slope and maximum. This confirms previous findings on the effect of phloretin on the voltage dependence of the fast macroscopic K conductance. Single channel conductance and deactivation kinetics were not altered by phloretin.

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The effect of phloretin (20-100 gM), a dipolar organic compound, on the voltage clamp currents of the frog node of Ranvier has been investigated. The Na currents are simply reduced in size but not otherwise affected. Phloretin has no effect on the slow 4-aminopyridineresistant K channels. However, t