The Effect of Phenylalanine on DOPA Synthesis in PC12 Cells
β Scribed by Frank R. DePietro; John D. Fernstrom
- Book ID
- 110403165
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 947 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0364-3190
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The effects of dopamine and L-DOPA on survival were examined in differentiated PC12 cells. Addition of dopamine to the culture medium at 3-30 M prevented cell death induced by depletion of serum and nerve growth factor (NGF). At 100 M, dopamine induced cell death. The cell-protective effect of dopam
## Abstract The effects of scoparone on dopamine biosynthesis and LβDOPAβinduced cytotoxicity in PC12 cells were investigated. PC12 cells treated with scoparone at concentrations of 100β200 ΞΌM showed a 128β136% increase in dopamine levels over the course of 24 hr. Scoparone significantly increased