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The effect of pH on thein vitro degradation of poly(glycolide lactide) copolymer absorbable sutures

✍ Scribed by Chu, C. C.

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
436 KB
Volume
16
Category
Article
ISSN
0021-9304

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✦ Synopsis

Abstract

The pH effect on the hydrolytic degradation of Polyglactin 910 copolymer was studied in terms of the tensile properties of the suture specimens. The use of a cord/yarn grip, newly designed specifically for fibrous materials, eliminated the grip‐induced failure. Different degrees of hydrolytic degradation of this copolymer at 3 different pH levels were observed. The suture specimens exhibited the best retentions of breaking strength at the physiological pH of 7.44, while the specimens at pH = 10.09 showed the fastest loss of breaking strength. Thus, a maximum retention of tensile properties occurred around the pH level of 7.0, whereas smaller percentages of retention of tensile properties were observed at both acidic and strong alkaline solutions. This synthetic absorbable suture material exhibits the basic characteristic of hydrolysis which is catalyzed by both acid and base.

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