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The Effect of PEG Crystallization on the Morphology of PEG/Peptide Block Copolymers Containing Amyloid β-Peptide Fragments

✍ Scribed by Marta J. Krysmann; Sérgio S. Funari; Elisabetta Canetta; Ian W. Hamley

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
306 KB
Volume
209
Category
Article
ISSN
1022-1352

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✦ Synopsis

Abstract

Ordered nanostructures are observed in the melt and solid state for a series of three peptide/PEG conjugates containing fragments of amyloid β‐peptides. These are conjugated to PEG with $\overline M _{\rm n}$ = 3 300 g · mol^−1^ and a melting temperature T~m~ = 45–50 °C. The morphology at room temperature is examined by AFM and POM. This shows spherulite formation for the weakly fibrillizing KLVFF‐PEG sample but fibril formation for FFKLVFF‐PEG. The fibrillization tendency of the latter is enhanced by multiple phenylalanine residues. Simultaneous SAXS and WAXS was used to investigate the morphology as a function of temperature. The secondary structure is probed by FTIR.

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