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The effect of parathyroid hormone on technetium-99m pyrophosphate distribution in rats

✍ Scribed by Samuel E. Halpern; Phillip L. Hagan; Depew M. Chauncey; Phillip Ayers

Publisher
Springer
Year
1980
Tongue
English
Weight
408 KB
Volume
5
Category
Article
ISSN
0340-6997

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✦ Synopsis

Sprague-Dawley rats were treated with varying quantities of parathyroid hormone for 1--3 days, then sacrificed at periods ranging from 1--6 h after administration of 99mTc-pyrophosphate. Very little increase in bone accumulation of tracer occurred with this treatment. A small, but obvious decrease occurred in the blood levels of 99mTc-pyrophosphate and a smaller and less consistent decrease was affected in the muscle levels of the radiopharmaceutical. The overall result was an improvement in the bone/blood and bone/muscle ratios. It is suggested that the basis of the "supernormal" bone scan of hyperparathyroidism is achieved by this mechanism and that the increased bone uptake of other ions in response to parathyroid hormone is not shared by 99mTc-pyrophosphate.

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✍ Luke Harris; John Yoo; Albert Driedger; Kevin Fung; Jason Franklin; Daryl Gray; πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 323 KB

## Abstract ## Background. This study evaluated the accuracy of single photon emission computed tomography (SPECT)‐CT imaging for the preoperative localization of parathyroid adenomas. ## Methods. This study included both a quantitative and qualitative accuracy measure. The quantitative measure