The effect of P-glycoprotein and cytochrome P450 3a on the oral bioavailability of vinorelbine in mice
โ Scribed by Rogier R. Press; Tessa Buckle; Jos H. Beijnen; Olaf van Tellingen
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 285 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Dextromethorphan (DXM) is commonly used as a probe for the metabolic activity of the debrisoquine isozyme (P-450 lID6) of the cytochrome P-450 mixed-function oxidase system. Several reports have described changes in P-450 activity with dietary alteration. This study was conducted to determine the ef
Antisense phosphorodiamidate Morpholino oligomers (PMO) are resistant to degradation by cellular hydrolases, DNases, RNases, and phosphodiesterases, but remain sensitive to prolonged exposure to low pH. The present studies evaluate the oral fractional bioavailability, stability, and efficacy of two
The coordination of the functional activities of intestinal CYP3A4 and P-gp in limiting the absorption of xenobiotics in Caco-2 cells was investigated. Growing Caco-2 cells were exposed to increasing concentrations of doxorubicin (1ยฑ2 mM) in plastic ยฏasks to encourage a subpopulation of cells, that