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The effect of oral phenobarbitone on hepatic microsomal cytochrome P-450 and demethylation activity in rats fed normal and low protein diets

✍ Scribed by W.J. Marshall; A.E.M. McLean


Book ID
115769981
Publisher
Elsevier Science
Year
1969
Tongue
English
Weight
382 KB
Volume
18
Category
Article
ISSN
0006-2952

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Dextromethorphan (DXM) is commonly used as a probe for the metabolic activity of the debrisoquine isozyme (P-450 lID6) of the cytochrome P-450 mixed-function oxidase system. Several reports have described changes in P-450 activity with dietary alteration. This study was conducted to determine the ef