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The Effect of Octanoic Acid on the Binding of the Enantiomers of Ibuprofen and Naproxen to Human Serum Albumin: A Chromatographic Implication

โœ Scribed by Vandana K. Cheruvallath; Christopher M. Riley; Sunanda R. Narayanan; Siegfried Lindenbaum; John H. Perrin


Book ID
110344986
Publisher
Springer US
Year
1996
Tongue
English
Weight
959 KB
Volume
13
Category
Article
ISSN
0724-8741

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โœ Tomoo Itoh; Yoshikazu Saura; Yasuyuki Tsuda; Hideo Yamada ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 196 KB ๐Ÿ‘ 2 views

Binding of ibuprofen (IB) enantiomers to human serum albumin (HSA) was studied using a chiral fluorescent derivatizing reagent, which enabled the measurement of IB enantiomers at a concentration as low 5 x 10(-8) M. Scatchard analyses revealed that there were two classes of binding sites for both en