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The effect of novel nucleoside analogues on normal and neoplastic immune cells

โœ Scribed by Ionela Victoria Neagoe; Monica Neagu; Carolina Constantin; Constantin Tanase; Gina Manda

Book ID
119379522
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
82 KB
Volume
172
Category
Article
ISSN
0378-4274

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Gemcitabine (2',2'difluoro-2'deoxycytidine, dFdC) is a synthetic antimetabolite of the cellular pyrimidine nucleotide metabolism. In a first series of in vitro experiments, the drug showed a strong effect on the proliferation and colony formation of the human androgen-sensitive tumor cell line LNCaP