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The effect of nitrosoguanidine upon DNA synthesis in vitro

✍ Scribed by Jiménez-Sánchez, Alfonso

Publisher
Springer
Year
1976
Tongue
English
Weight
494 KB
Volume
145
Category
Article
ISSN
0026-8925

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✦ Synopsis

Both the polymerase and the exonuclease activities of DNA polymerase III are inactivated by treatment with nitrosoguanidine. The treatment of the DNA template with the mutagen does not affect the template in supporting DNA synthesis. No effect of nitrosoguanidine upon fidelity of replication in vitro was detected.

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Effect of DNA inhibitors upon DNA synthe
Effect of DNA inhibitors upon DNA synthesis and development ofDrosophila embryos
✍ Parente, Anthony ;Arking, Robert ;Kalata, Karen 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 762 KB

## Abstract Staged wildtype embryos __Drosophila melanogaster__ were permeabilized and then subjected to a short pulse of either methyl‐^3^H‐thymidine, one of four different inhibitors of DNA synthesis (mitomycin C, 5‐fluorouracil, nalidixic acid, or 1‐β‐D‐arabino‐furanosylcytosine‐5′‐monophosphate