The effect of nitrogen mustard on the distribution of radioiron in man

✍ Scribed by Montague Lane; Nathaniel I. Berlin; Charles E. Mengel

• Publisher: John Wiley and Sons
• Year: 1964
• Tongue: English
• Weight: 509 KB
• Volume: 17
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(196403)17:3<322::aid-cncr2820170308>3.0.co;2-3

✦ Synopsis

NITROGEN MUS-T tard (HNZ) on the hematopoietic system have been repeatedly documented in animals and in man. Bertinchamps et al.1 demonstrated that administration of H N 2 temporarily decreased the rate of turnover of plasma iron.

The plasma radioiron clearance Ty2, the time necessary for a 50y0 reduction in the radioactivity of the plasma sample, increased sharply between the second and fourth day after H N 2 administration and returned to preinjection levels between the tenth and fifteenth day. Plasma iron concentrations similarly initially increased and then decreased.

The present studies were undertaken to evaluate the effects of nitrogen mustard on