The effect of nicotine on the swimming speed of pre-trained rats through a water alley

✍ Scribed by K. Bättig

• Book ID: 104762720
• Publisher: Springer
• Year: 1969
• Tongue: English
• Weight: 483 KB
• Volume: 15
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00410797

✦ Synopsis

In sessions of ten runs each, swimming lime of rats through a 4 m long water alley was measured. Four doses of nicotine (0.05; 0.1; 0.2; 0.4 mg/kg given intraperitoneally 30 minutes before testing) were tested in sessions with a braking load on the tails of the animals either in all 10 runs of a session, or in every second run, or in none of the 10 runs. Regardless of the swimming condition, nicotine produced a considerable, and at doses of 0.1 mg/kg and over, significant decrease of performance in the first two runs. From the third to the 10th run, the changes caused by nicotine were smaller and differed depending on the swimming conditions.

A dose of 0.1 mg nieotine/kg improved performance in the "without-loadsessions" and the "without-load-runs" of the alternating sessions, while both 0.1 and 0.2 mg/kg improved performance of the "with-load-runs" of the alternating sessions. Performance in the "without-load-sessions" and the "without-load-runs" was depressed by 0.4 mg/kg and that in the "with-load-sessions" by 0.2 and 0.4 mg/kg.