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The effect of nerve growth factor and limb regeneration on the spinal and sympathetic ganglia ofTriturus

✍ Scribed by Grillo, R. S. ;Detmar, C. F. ;Mitchell, O. G.

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
727 KB
Volume
202
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

In Triturus administration of NGF causes hypertrophy of neuronal perikarya of third dorsal root ganglia and post‐subclavian sympathetic ganglia.

Two classes of neurons were characterized cytologically in the third dorsal root ganglia. Some evidence is presented which indicates that Class I neurons respond more vigorously to NGF. It is suggested that Class I neurons are similar to the medio‐dorsal neuroblasts of chick embryos in their response to NGF.

Forelimb amputation did not cause neuronal hypertrophy in either third dorsal root ganglia or post‐subclavian sympathetic ganglia.

The incorporation of (^3^H)‐uridine increases to a highly significant extent in third dorsal root ganglia following NGF treatment or limb amputation. When NGF treatment and limb amputation were combined, no further increase in (^3^H)‐uridine incorporation was noted. This suggests that RNA synthesis is maximally stimulated by either NGF treatment alone or limb amputation alone.

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