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The effect of morphine and some other narcotic analgesics on brain tryptophan concentrations

✍ Scribed by A. W. A. Crossley; P. Slater

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
432 KB
Volume
4
Category
Article
ISSN
0360-4012

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✦ Synopsis

An acute dose of morphine increased brain tryptophan in mice. 7 his effect was not prevented by naloxone nor was it produced by other narcotic analgesics. Dextrorphan, but not levorphanol. had a similar effect t o morphine. A large dose of tryptophan had no effect on the antinociceptive action of morphine in mice. Morphine increased brain tryptophan in rats. This effect was prevented by naloxone. A large dosc of tryptophan antagonised the antinociceptive action of morphine in the rat.

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