✦ LIBER ✦

The effect of memantine on sleep behaviour in dementia with Lewy bodies and Parkinson's disease dementia

✍ Scribed by Victoria Larsson; Dag Aarsland; Clive Ballard; Lennart Minthon; Elisabet Londos

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 206 KB
Volume: 25
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.2506

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Objective

Two common and characteristic sleep disturbances have been described in dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD); excessive daytime sleepiness and REM sleep behaviour disorder (RBD). This study is an analysis of a secondary outcome measure of a larger study already reported, aimed to determine whether memantine has an effect on the sleep disturbances in DLB and PDD patients.

Methods

Patients with DLB or PDD were included in a placebo‐controlled, randomised controlled study of memantine (20 mg per day) for 24 weeks. The Stavanger Sleep Questionnaire and the Epworth Sleepiness Scale were used to evaluate the effect on sleep disturbances.

Results

Forty two patients started treatment; 20 with memantine and 22 with placebo. The primary analysis was the comparison of change between the two groups during a 24‐week period, using the modified ITT population (last observation carried forward). At 24 weeks, patients treated with memantine were less physically active during sleep while patients in the placebo group worsened. Mean difference between the groups (0.5 [0.05–0.90]) was significant (p = 0.006). No significant change was observed in severity of excessive daytime sleepiness.

Conclusions

📜 SIMILAR VOLUMES

Pentagon drawing and neuropsychological

Pentagon drawing and neuropsychological performance in Dementia with Lewy Bodies, Alzheimer's disease, Parkinson's disease and Parkinson's disease with dementia

✍ Francesca Cormack; Dag Aarsland; Clive Ballard; Martin J. Tovée 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 91 KB 👁 2 views

## Abstract ## Objectives Early and accurate diagnosis of Dementia with Lewy Bodies (DLB) to allow the appropriate clinical treatment is a priority, given reports of severe neuroleptic sensitivity and a preferential response to cholinesterase inhibitors in these patients. There have been suggestio

A comparison of the efficacy of donepezi

A comparison of the efficacy of donepezil in Parkinson's disease with Dementia and Dementia with Lewy bodies

✍ Alan J. Thomas; David J. Burn; Elise N. Rowan; Elizabeth Littlewood; Jane Newby; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 81 KB 👁 1 views

Subjectively reported sleep quality and

Subjectively reported sleep quality and excessive daytime somnolence in Parkinson's disease with and without dementia, dementia with Lewy bodies and Alzheimer's disease

✍ Frauke Boddy; Elise N Rowan; Debbie Lett; John T O'Brien; Ian G McKeith; David J 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 101 KB 👁 1 views

## Abstract ## Objective We compared subjective sleep quality and excessive daytime somnolence (EDS) in controls, Parkinson's disease with (PDD) and without dementia (PD), dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). We investigated whether sleep dysfunction and EDS associate with

A comparative study of psychiatric sympt

A comparative study of psychiatric symptoms in dementia with Lewy bodies and Parkinson's disease with and without dementia

✍ Dag Aarsland; Clive Ballard; Jan P. Larsen; Ian McKeith 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB 👁 1 views

## Abstract ## Objectives To compare the frequency and clinical correlates of neuropsychiatric symptoms in patients with Parkinson's disease (PD) with and without dementia and in those with dementia with Lewy bodies (DLB). ## Methods Neuropsychiatric symptoms during the month prior to assessment

A comparison of sleep profiles in patien

A comparison of sleep profiles in patients with dementia with Lewy bodies and Alzheimer's disease

✍ J. B Grace; M. P Walker; I. G McKeith 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 60 KB 👁 2 views

Introduction[ Sleep disturbances are common in healthy old age and in dementia syndromes[ Polysomnography has demonstrated typical changes in both Alzheimer|s disease "AD# and dementia with Lewy bodies "DLB# with AD being characterised by sundowning and sleep apnoea and DLB patients showing more dis

The progression of cognitive impairment

The progression of cognitive impairment in dementia with Lewy bodies, vascular dementia and Alzheimer's disease

✍ C. Ballard; J. O'Brien; C. M. Morris; R. Barber; A. Swann; D. Neill; I. McKeith 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 63 KB 👁 2 views

## Abstract ## Background Little is known about the rate of progression or associations of cognitive impairment in dementia with Lewy bodies (DLB), or the associations of accelerated decline. ## Method Dementia patients from a case register were evaluated at baseline and 1 year follow‐up using t