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The Effect of LXR Activators on AP-1 Proteins in Keratinocytes

✍ Scribed by Schmuth, Matthias; Elias, Peter M.; Hanley, Karen; Lau, Peggy; Moser, A.; Willson, Timothy M.; Bikle, Daniel D.; Feingold, Kenneth R.


Book ID
110733204
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
434 KB
Volume
123
Category
Article
ISSN
0022-202X

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Okadaic acid (OA), a specific inhibitor of protein phosphatases 1 and 2A, is also a potent mouse skin tumor promoter. The effects of OA on regulation of c-jun/activator protein-1 (AP-1) transcriptional activation were investigated in mouse keratinocytes. AP-1 DNA binding to the jun 12-O-tetradecanoy