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The effect of Lp3 enlargement on the folding and catalysis of hepatitis delta virus cis-cleaving ribozyme

✍ Scribed by Huey-Nan Wu; Jing-Yu Lee; Yueh-Hsin Ping; Chen-Nai Wang


Book ID
117110019
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
227 KB
Volume
439
Category
Article
ISSN
0014-5793

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## Abstract The self‐cleaving hepatitis delta virus (HDV) ribozyme is essential for the replication of HDV, a liver disease causing pathogen in humans. The catalytically critical nucleotide C75 of the ribozyme is buttressed by a trefoil turn pivoting around an extruded G76. In all available crystal