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The effect of low ph and hypoxia on the cytotoxic effects of SR4233 and mitomycin C in vitro

โœ Scribed by Lloyd D. Skarsgard; Adriana Vinczan; Mark W. Skwarchuk; David J. Chaplin


Book ID
107964869
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
571 KB
Volume
29
Category
Article
ISSN
0360-3016

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To evaluate the effects of anaerobic conditions and inducers for the mixed-function oxidase system on the metabolism of mitomycin C, a bioreductive alkylating agent widely used for the treatment of hepatocellular carcinoma, experiments so designed were performed in rats and mice. Metabolism of mitom