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The Effect of Local Production of Cytokines in the Pathogenesis of Insulin-Dependent Diabetes Mellitus

✍ Scribed by Marika Falcone; Nora Sarvetnick


Book ID
118768260
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
66 KB
Volume
90
Category
Article
ISSN
1090-2341

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Correlation studies between cytokines expressed in islets and autoimmune diabetes development in NOD mice and BB rats have demonstrated that ␀-cell destructive insulitis is associated with increased expression of proinflammatory cytokines (IL-1, TNF␣, and IFN␣) and type 1 cytokines (IFNβ₯, TNF␀, IL-2