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The effect of L-buthionine sulfoximine on the aerobic radiation response of A549 human lung carcinoma cells

✍ Scribed by John E. Biaglow; Marie E. Varnes; Steven W. Tuttle; Nancy L. Oleinick; Karen Glazier; Edward P. Clark; Edward R. Epp; Lyle A. Dethlefsen


Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
445 KB
Volume
12
Category
Article
ISSN
0360-3016

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Effect of buthionine sulfoximine on PtII
✍ Prakash Mistry; Swee Y. Loh; Lloyd R. Kelland; Ken R. Harrap πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 French βš– 752 KB

## Abstract Glutathione (GSH) has often been implicated in the mechanism of resistance to platinum anti‐cancer drugs. It has been suggested that GSH may reduce the cytotoxicity of these drugs by forming inactive conjugates and by enhancing the repair of DNA‐platinum crosslinks. In the present study