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The effect of IVl-tryptophan on prolactin, growth hormone, and mood in healthy subjects

✍ Scribed by Dennis S. Charney; George R. Heninger; John F. Reinhard; David E. Sternberg; Karen M. Hafstead

Publisher: Springer
Year: 1982
Tongue: English
Weight: 657 KB
Volume: 78
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00470585

No coin nor oath required. For personal study only.

✦ Synopsis

In order to assess the effects of increased CNS serotonergic function in humans on prolactin (PRL), growth hormone (GH), and mood, IV L-tryptophan (TRP) was administered to ten healthy subjects. The TRP infusion induced robust increases in PRL in all ten subjects. A significant increase in GH concentration was also observed, although the response was more variable. The subjects reported feeling significantly more 'high', 'mellow', and 'drowsy' following the TRP infusion in comparison to placebo. These findings indicate an important role for serotonin in PRL and Gtt secretion, as well as in mood regulation. The IV TRP challenge may be of use in the study of serotonergic function in a variety of neurologic and psychiatric diseases.

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