Re-calculating the sample size in intern
Re-calculating the sample size in internal pilot study designs with control of the type I error rate
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Meinhard Kieser; Tim Friede
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Article
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2000
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John Wiley and Sons
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English
โ 161 KB
๐ 2 views
When designing a clinical trial, there is usually some uncertainty about the variability of the primary outcome variable. This may lead to an unnecessarily high or inadequately low sample size. The internal pilot study approach uses data from patients recruited up to an interim stage to re-estimate