This paper presents the experimental result of a study on the effects of heat transfer enhancement on two-phase flow instabilities in a horizontal in-tube flow boiling system. Five different heat transfer surface configurations and five different inlet temperatures are used to observe the effect of heat transfer enhancement and inlet subcooling. All experiments are carried out at constant heat input, system pressure and exit restriction. Dynamic instabilities, namely pressure-drop type, density-wave type and thermal oscillations are found to occur for all the investigated temperatures and enhancement configurations, and the boundaries for the appearance of these oscillations are found. The effect of the enhancement configurations on the characteristics of the boiling flow dynamic instabilities is studied in detail. The comparison between the bare tube and the enhanced tube configurations are made on the basis of boiling flow instabilities. Differences among the enhanced configurations are also determined to observe which of them is the most stable and unstable one. The amplitudes and periods of pressure-drop type oscillations and density-wave type oscillations for tubes with enhanced surfaces are found to be higher than those of the bare tube. The bare tube is found to be the most stable configuration, while tube with internal springs having bigger pitch is found to be the most unstable one among the tested tubes. It is found that system stability increases with decreasing equivalent diameter for the same type heater tube configurations; however, on the basis of effective diameter there is no single result such as stability increase/decrease with increasing/decreasing effective diameter.