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The effect of inhibitors of prolyl endopeptidase and pyroglutamyl peptide hydrolase on TRH degradation in rat serum

✍ Scribed by Theodore C. Friedman; Sherwin Wilk


Book ID
115758784
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
506 KB
Volume
132
Category
Article
ISSN
0006-291X

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Evidence for pyroglutamyl peptidase I an
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Thyrotropin-Releasing hormone (TRH)-degrading pyroglutamyl peptidase I (PGP I) and prolylendopeptidase (PE) activities have been demonstrated in rat insulinoma RINm 5F cell line. These two enzymes catalyze the conversion of TRH to Histydyl-Proline-Diketopiperazine and to acid TRH respectively. After