The effect of inhibition of myosin light chain kinase by Wortmannin on intracellular [Ca2+], electrical activity and force in phasic smooth muscle

Effects of a myosin light chain kinase i

Effects of a myosin light chain kinase inhibitor, wortmannin, on cytoplasmic Ca2+levels, myosin light chain phosphorylation and force in vascular smooth muscle

✍ Makoto Takayama; Hiroshi Ozaki; Hideaki Karaki 📂 Article 📅 1996 🏛 Springer-Verlag 🌐 English ⚖ 870 KB

Biochemical studies have shown that wortmannin is an inhibitor of myosin light chain (MLC) kinase (Nakanishi et al. (1992) J. Biol. Chem. 267: 2157-2163). To investigate the role of MLC kinase in smooth muscle contractions, we examined the effects of wortmannin on isolated smooth muscles of the rat