Jha, K., Roy, B.K. and Sir@, R.C.P., 1996. The effect of induced fever on the biokinetics of norfloxacin and its interaction with prober&d in goats. Veterkaary Research Communications, %I Q, 473-479
The kinetic profiles of norlloxacin were evaluated in afebrile, febrile and probenecid pre-treated (70 mg/kg orally) febrile goats after a single intravenous (i.v.) dose (5 mg/kg). Fever was induced and maintained for 12 h by injecting Escherichia coli endotoxin (0.2 ugglkg, i.v.) and repeating it in half the dose (0.1 pg/kg) 5 h later. The plasma pharmacokinetic values for nortloxacin were best represented using a two-compartment open model. The peak noriloxacin plasma level of 90.52k3.18 ug/ml attained in the probenecid pm-treated febrile goats was higher than that in the febrile (75.46kO.72 pghl) or afebrile goats (62.25 f 1.23 uglml). Cln and & values were significantly (p<O.Ol) decreased in febrile compared with afebrile goats. These values were further reduced in febrile goats after probenecid pre-treatment. However, tkp was not affected by the fever-probenecid interaction.
NorfIoxacin may be used as an infusion with probenecid in caprine diseases where very high plasma levels are required to combat resistant organisms such as Bacterotdes.