The effect of indomethacin on cartilage breakdown
✍ Scribed by F. M. Desa; C. L. Chander; A. R. Moore; D. W. Howat; D. G. Corry; D. A. Willoughby
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 1989
- Tongue
- English
- Weight
- 170 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1420-908X
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## Abstract When 160 γg/ml sodium salicylate was added to the culture medium, glycosaminoglycan synthesis in slices of normal articular cartilage from habitually loaded areas of canine femoral condyles was diminished by 24% (__P__ ≤ 0.01). Although glycosaminoglycan synthesis in cartilage from habi
The effects of salicylate and indomethacin on glycosaminoglycan (GAG) synthesis by atrophic and osteoarthritic (OA) canine cartilage were examined in vitro by transecting distal femora at the metaphysis and incubating the knuckle, with its overlying cap of articular cartilage, in medium containing s