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The effect of hypoxaemia on drug disposition in chronic respiratory failure

โœ Scribed by D. Rowett; K. Latimer; L. N. Sansom; R. E. Ruffin; F. May; G. Henderson; P. J. Hayball; Received: February 1995/Accepted May


Book ID
105922492
Publisher
Springer
Year
1996
Tongue
English
Weight
263 KB
Volume
50
Category
Article
ISSN
0031-6970

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The pharmacokinetic disposition of tolfenamic acid, an NSAID, after a single administration of tolfenamic acid (4 mg kg 71 ) by the intravenous (IV) route was compared in eight dogs before and after a surgically induced renal failure. Renal impairment was conยฎrmed by a signiยฎcant increase ( p50ยด001)