The effect of hypertransfusion on the growth of mouse foetal liver cells transplanted into irradiated, adult recipients: Failure to detect a differential effect between cells from early and late foetuses
✍ Scribed by R. G. Tarbutt; R. J. Cole
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 551 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0021-9541
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✦ Synopsis
Abstract
Erythropoiesis can be reinstated in lethally irradiated mice by transplantation of adult bone marrow or liver cells from foetuses at any stage of gestation beyond the eleventh day. Hypertransfusion of the recipients abolishes erythropoiesis resulting from the transplants, even when the transplants are derived from foetuses at a very early stage of development. This suggests that erythropoietin is necessary for the successful growth of these early foetal transplants, at least in the environment of the irradiated recipient. These results are at variance with an earlier report on the susceptibility of early foetal liver transplants to suppression by hypertransfusion.