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The effect of hydrogen peroxide / L-histidine-induced DNA single- vs. double-strand breaks on poly(ADP-ribose)polymerase

✍ Scribed by Letizia Palomba; Andrea Guidarelli; Flaminio Cattabeni; Orazio Cantoni


Book ID
113398961
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
698 KB
Volume
291
Category
Article
ISSN
0922-4106

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Effect of a poly(ADP-ribose) polymerase
✍ LuΓ­sa CristΓ³vΓ£o; JosΓ© Rueff πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 695 KB

The activity of poly(ADP-ribose) polymerase (PARP) is activated upon recognition of DNA strand breaks by its DNA-binding domain and the stimulation of this nuclear enzyme seems to be an early response of cells exposed to a variety of different DNA-damaging agents. In the present work we evaluate the