The effect of hydralazine on the tumor cytotoxicity of the hypoxic cell cytotoxin RSU-1069: Evidence for therapeutic gain
β Scribed by David J. Chaplin; Brian Acker
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 850 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0360-3016
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Extensively conjugated cationic molecules with appropriate structural features naturally accumulate into the mitochondria of living cells, a phenomenon typically more prominent in tumor than in normal cells. Because a variety of tumor cells also retain pertinent cationic structures for longer period
## Abstract The effects of H^+^ on the kinetics of Ξ±βaminoisobutyric acid (AIB) influx in Ehrlich ascites tumor cells have been investigated at different external Na^+^ concentrations. Elevation of [H^+^] in the presence of both high (154 mEq/l) and low (10 mEq/l) external Na^+^ leads to decreases