## Abstract Three experiments examined the doseβdependent biphasic effect of morphine on odor conditioning in neonatal rats. In Experiment 1, a single pairing of an odor and a low dose of morphine (0.5 mg/kg) in 5βdayβold rats produced an odor preference, relative to an unpaired control group. In E
The effect of housing and gender on preference for morphine-sucrose solutions in rats
β Scribed by Patricia F. Hadaway; Bruce K. Alexander; Robert B. Coambs; Barry Beyerstein
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 435 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
β¦ Synopsis
To determine whether opiate consumption is affected by laboratory housing, individually caged and colony rats were given a choice between water and progressively more palatable morphine-sucrose solutions. The isolated rats drank significantly more of the opiate solution, and females drank significantly more than males. In the experimental phase during which morphine-sucrose solution consumption was greatest, the isolated females drank five times as much, and the isolated males sixteen times as much morphine (mg/kg) as the colony females and males respectively.
π SIMILAR VOLUMES
In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,
Morphine induces a larger locomotor stimulation in the alcohol-preferring AA rats than in the alcohol-avoiding ANA rats. We have now studied the acute effects of morphine (1 and 3 mg/kg) on metabolism of dopamine and serotonin (5-HT) in the dorsal and ventral striatum of the AA and ANA rats. The bas