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The Effect of High Dose Endotoxin on CYP3A2 Expression in the Rat

โœ Scribed by Amy L. Roe; Graham Warren; Guoqiang Hou; Georgette Howard; Steven I. Shedlofsky; Robert A. Blouin


Book ID
110305241
Publisher
Springer US
Year
1998
Tongue
English
Weight
626 KB
Volume
15
Category
Article
ISSN
0724-8741

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In the treatment of cardiac arrhythmias, amiodarone (AM) has emerged as a primary therapeutic agent. In addition to other cytochrome P450 (CYP), 1A1 and 1A2 facilitate the biotransformation of AM to the pharmacologically and toxicologically active metabolite, desethylamiodarone (DEA). The exposure t