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The effect of gramicidin A on phospholipid bilayers

✍ Scribed by B. A. Cornell; L. E. Weir; F. Separovic

Publisher
Springer
Year
1988
Tongue
English
Weight
697 KB
Volume
16
Category
Article
ISSN
1432-1017

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✦ Synopsis

The helical polypeptide, gramicidin A has been widely studied as a model for the interactions of hydrophobic proteins with lipid bilayer membranes. Many reports are now available of the physical effects of mixing gramicidin A with phospholipid membranes, however, the interpretation of these data remains unclear. The purpose of this communication is to examine the controversial claim that high concentrations of gramicidin A' cause disorder within the L alpha phase of phosphatidylcholine-water dispersions. Solid-state nuclear magnetic resonance (NMR), density gradient and X-ray diffraction techniques are used to confirm the existence of such an effect and mechanisms are discussed which account for the known effects of gramicidin A on lipid bilayers.

πŸ“œ SIMILAR VOLUMES

Molecular dynamics studies of lipid bila
Molecular dynamics studies of lipid bilayer with gramicidin A: Effects of gramicidin a on membrane structure and hydrophobic match
✍ Hiroaki Saito; Taku Mizukami; Shuhei Kawamoto; Takeshi Miyakawa; Masashi Iwayama πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 1023 KB

## Abstract The effects of gramicidin A (GA) peptide on the structure of lipid bilayer were studied by molecular dynamics (MD) simulations in the absence and presence of GA peptide. The hydrophobic match between the GA and surrounding lipid bilayer was investigated by the MD simulations of four kin