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The effect of glucose on 11β- and 19-hydroxylation of reichstein's substance S byPellicularia filamentosa

✍ Scribed by T. A. Clark; I. S. Maddox; R. Chong

Publisher: Springer
Year: 1983
Tongue: English
Weight: 512 KB
Volume: 17
Category: Article
ISSN: 1432-0614
DOI: 10.1007/bf00510417

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✦ Synopsis

Experiments in batch-fermenters have demonstrated that the llfi-and 19-hydroxylation of Reichstein's Substance S by Pellicularia filamentosa ceases in the absence of glucose. The effects of glucose consumption rate and growth rate on hydroxylation have been investigated using chemostat cultures. With glucose-limited cultures, increased hydroxylation rates were observed with increased glucose consumption rates. With nitrogen-limited cultures, however, some form of glucose-repression exists. The maximum rate of hydroxylation occurred at a glucose consumption rate at which the culture was just nitrogen-limited. The growth rate had no major importance.

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