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The effect of gamma irradiation on collagen fibril structure

✍ Scribed by I. Leontiou; D.P. Matthopoulos; M. Tzaphlidou; D. Glaros

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
725 KB
Volume
24
Category
Article
ISSN
0968-4328

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✦ Synopsis

The structure of mouse skin collagen fibrils treated with 500 rad gamma irradiation was studied by electron microscopy. Examination of specimens after 1, 4 and 8 weeks of treatment revealed collagen fibrils consistently larger in diameter than those from normal specimens with the majority of irradiated fibrils measuring 1 lo-138 nm, as opposed to 62-84 nm in the control. No marked differences in cross-linking were detected between irradiated and control reconstituted type I or type III collagen, either by polyacrylamide gel electrophoresis or by thermal stability measurements.

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